Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects.
Product Details
| Alternative Name: | rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, AT-4140 |
| |
| Formula: | C19H22F2N4O3 |
| |
| MW: | 392.4 |
| |
| CAS: | 110871-86-8 |
| |
| MI: | 14: 8735 |
| |
| RTECS: | VB1986500 |
| |
| Purity: | ≥98% (Assay) |
| |
| Identity: | Determined by IR. |
| |
| Appearance: | White to yellow crystalline solid. |
| |
| Solubility: | Soluble in 100% ethanol or water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother.
51, 576 (2007),
Abstract;
Full Text
Sparfloxacin: a review: J.J. Schentag; Clin. Ther.
22, 372 (2000), (Review),
Abstract;
The link between sunshine and phototoxicity of sparfloxacin: C. Pierfitte, et al.; Br. J. Clin. Pharmacol.
49, 609 (2000),
Abstract;
Full Text
Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria: L.J. Piddock & M. Zhu; Antimicrob. Agents Chemother.
35, 2423 (1991),
Abstract;
Full Text
Pharmacokinetics of a novel quinolone, AT-4140, in animals: S. Nakamura, et al.; Antimicrob. Agents Chemother.
34, 89 (1990),
Abstract;
Full Text
Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency: T. Miyamoto, et al.; J. Med. Chem.
33, 1645 (1990),
Abstract;
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone: S. Nakamura, et al.; Antimicrob. Agents Chemother.
33, 1167 (1989),
Abstract;
Full Text
