Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits the generation of O2- and OH radicals by neutrophils. Inhibits the production of inflammatory cytokines.
Product Details
| Alternative Name: | 9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, Jinofloxacin, OPC-7251 |
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| Formula: | C19H21FN2O4 |
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| MW: | 360.4 |
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| CAS: | 124858-35-1 |
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| MI: | 14: 6345 |
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| Purity: | ≥98% (Assay) |
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| Identity: | Determined by IR. |
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| Appearance: | White to yellow crystalline solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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7, 1957 (2006),
Abstract;
Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes: K. Kuwahara, et al.; J. Dermatol. Sci.
38, 47 (2005),
Abstract;
Activity of nadifloxacin (OPC-7251) and seven other antimicrobial agents against aerobic and anaerobic Gram-positive bacteria isolated from bacterial skin infections: P. Nenoff, et al.; Chemotherapy
50, 196 (2004),
Abstract;
Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin resistance in clinically isolated quinolone-resistant Staphylococcus aureus: N. Oizumi, et al.; J. Infect. Chemother.
7, 191 (2001),
Abstract;
Effect of nadifloxacin on neutrophil functions: H. Akamatsu, et al.; J. Int. Med. Res.
23, 19 (1995),
Abstract;
Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris: K. Vogt, et al.; Eur. J. Clin. Microbiol. Infect. Dis.
11, 943 (1992),
Abstract;
Clinical and bacteriologic evaluation of OPC-7251 in patients with acne: a double-blind group comparison study versus cream base: I. Kurokawa, et al.; J. Am. Acad. Dermatol.
25, 674 (1991),
Abstract;
Studies on antibacterial agents. I. Synthesis of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids: H. Ishikawa, et al.; Chem. Pharm. Bull.
37, 2103 (1989),
Abstract;
