Aminoglycoside antibiotic. Binds to the 70S ribosomal subunit. Inhibits translocation and elicits miscoding. Interaction with ribosomes may be prevented by aminoglycoside modifying enzymes. Effective against Gram-negative and Gram-positive bacteria and mycoplasma.
Product Details
| Formula: | C18H36N4O11 . H2SO4 |
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| MW: | 484.5 . 98.1 |
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| Source: | Isolated from Streptomyces kanamyceticus. |
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| CAS: | 25389-94-0 |
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| MI: | 14: 5281 |
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| RTECS: | NZ3225030 |
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| Appearance: | White to off-white crystalline powder. |
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| Activity: | Potency is >750µg/ml (on dry basis). |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antibiotic MICs and short time-killing against Helicobacter pylori: therapeutic potential of kanamycin: Y. Irie, et al.; J. Antimicrob. Chemother.
40, 235 (1997),
Abstract;
Interaction of kanamycin A and kanamycin B with phospholipids: M.W. Yung & C. Green; J. Antibiot.
40, 862 (1987),
Abstract;
Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production: K. Basak & S.K. Majumdar; Antimicrob. Agents Chemother.
4, 6 (1973),
Abstract;
Full Text
The total synthesis of kanamycin A: S. Umezawa, et al.; J. Antibiot.
21, 367 (1968),
Abstract;
Infection of the protoplasts of Streptomyces kanamyceticus with deoxyribonucleic acid preparation from actinophage PK-66: M. Okanishi, et al.; J. Bacteriol.
92, 1850 (1966),
Abstract;
Full Text
Studies on Streptomyces kanamyceticus, producer of kanamycin: Y. Okami, et al.; J. Antibiot.
12, 252 (1959),
Abstract;
