Antibiotic. Dominant analog of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Displays antiproliferative as well as potent antifungal activity. Induces apoptosis in osteoclasts thus inhibiting bone resorption.
Product Details
Formula: | C36H52O11 |
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MW: | 660.8 |
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Source: | Isolated from Streptomyces sp. MST-AS5344. |
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CAS: | 134615-37-5 |
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Formulation: | Lyophilized. |
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Purity: | ≥99% (HPLC) |
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Appearance: | White to tan solid. |
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Solubility: | Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone: S. Sone and S. Yano; Cancer Metastasis Rev.
26, 685 (2007),
Abstract;
Regulation of osteoclast polarization: N. Takahashi, et al.; Odontology
95, 1 (2007), (Review),
Abstract;
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts: J.T. Woo, et al.; PNAS
103, 4729 (2006),
Abstract;
Full Text
Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity: H. Muguruma, et al.; Clin. Cancer Res.
11, 8822 (2005),
Abstract;
Full Text
Chemical modification of reveromycin A and its biological activities: T. Shimizu, et al.; Bioorg. Med. Chem. Lett.
12, 3363 (2002),
Abstract;
Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A: Y. Miyamoto, et al.; J. Biol. Chem.
277, 28810 (2002),
Abstract;
Full Text
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties: H. Takahashi, et al.; J. Antibiot. (Tokyo)
45, 1409 (1992),
Abstract;
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities: H. Takahashi, et al.; J. Antibiot. (Tokyo)
45, 1414 (1992),
Abstract;