Macrolide antibiotic inhibiting testosterone 5-reductase and plasma-proton ATPase (P-ATPase). Shows antifungal, antiprotozoal, antitumor, antihelmintic and immunosuppressive activity.
Product Details
Alternative Name: | Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846 I, SNA 4606-3, Azalomycin B, Gopalamicin, Salbomycin |
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Formula: | C54H88O18 |
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MW: | 1025.3 |
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Source: | Isolated from Streptomyces sp. MT-1. |
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CAS: | 37318-06-2 |
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RTECS: | CL8380000 |
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Purity: | ≥95% (HPLC) |
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Identity: | Determined by 1H-NMR. |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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Shipping: | Ambient Temperature |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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Handling: | Protect from light when in solution. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Time lapse imaging analysis of the effect of ER stress modulators on apoptotic cell assessed by caspase3/7 activation in NG108-15 cells: A. Saito, et al.; Data Brief
6, 20 (2015),
Application(s): Cell culture,
Abstract;
In vitro and in vivo antiprotozoal activities of bispolides and their derivatives: K. Otoguro, et al.; J. Antibiot. (Tokyo)
63, 275 (2010),
Abstract;
Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes: P.A. Grigoriev, et al.; Bioelectrochemistry
54, 11 (2001),
Abstract;
Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties.: C. Cui, et al.; Chinese J. Antibiot. 26, 165 (2001),
Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin: A. Fang, et al.; J. Antibiot. (Tokyo)
53, 158 (2000),
Abstract;
SNA-4606-1, a new member of elaiophylins with enzyme inhibition activity against testosterone 5 alpha-reductase: M. Nakakoshi, et al.; J. Antibiot. (Tokyo)
52, 175 (1999),
Abstract;
Elaiophylin as a rumen fermentation efficiency enhancer: C.M. Liu, et al.; J. Antibiot. (Tokyo)
46, 350 (1993),
Abstract;
Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger: H.P. Fiedler, et al.; J. Antibiot. (Tokyo)
34, 1107 (1981),
Abstract;
Melanosporin and elaiophylin, new antibiotics from Streptomyces malanosporus (sive melanosporofaciens) n. sp.: F.M. Arcamone, et al.; G. Microbiol. 7, 207 (1959),