Inhibitor of DNA Gyrase, Staphylococcus aureus (IC50= 1.45µM), E.coli (IC50= 0.41µM). Antibacterial (gram-positive). Antitumor.
Product Details
| Formula: | C46H42ClNO18 |
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| MW: | 932.3 |
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| Source: | Isolated from Streptomyces antibioticus. |
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| CAS: | 301845-97-6 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO, dichloromethane, methanol, acetone or ethylacetate. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase: M.J. Edwards, et al.; Science
326, 1415 (2009),
Abstract;
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus: L.M. Oppegard, et al.; Antimicrob. Agents Chemother.
53, 2110 (2009),
Abstract;
Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB: C. Sissi, et al.; Antimicrob. Agents Chemother.
54, 213 (2009),
Abstract;
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action: R.H. Flatman, et al.; Antimicrob. Agents Chemother.
49, 1093 (2005),
Abstract;
Biosynthesis of simocyclinone D8 in an 18O2-rich atmosphere: M. Holzenkämpfer & A. Zeeck; J. Antibiot.
55, 341 (2002),
Abstract;
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 II. Structure elucidation and biosynthesis: M. Holzenkämpfer, et al.; J. Antibiot.
55, 301 (2002),
Abstract;
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040. I. Taxonomy, fermentation, isolation and biological activities: J. Schimana, et al.; J. Antibiot.
53, 779 (2000),
Abstract;
