Online Purchasing Account You are logged on as Guest. Login Register a New Account Shopping cart (Empty)

Sinefungin

Methyltransferase inhibitor



ALX-380-070-M001	1 mg	115.00 USD

ALX-380-070-M005	5 mg	403.00 USD
Do you need bulk/larger quantities?

Strong competitive inhibitor of methyltransferases which uses S-adenosyl-1-methionine as the methyl group donor to yield methylated products such as 5-methylcytosine or N⁶-methyl adenosine on DNA and RNA. In addition, sinefungin is involved in a number of physiological processes.

Product Details

Alternative Name:	6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-α-L-talo-decafuranuronic acid, A-9145, Adenosylornithine

Formula:	C₁₅H₂₃N₇O₅

MW:	381.4

CAS:	58944-73-3

MI:	14: 8544

RTECS:	HE3140000

Purity:	≥95% (HPLC)

Appearance:	White to yellow powder.

Solubility:	Soluble in water.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Keep under nitrogen. Packaged under nitrogen. Protect from light. Very hygroscopic.

Regulatory Status:	RUO - Research Use Only

Please mouse over

Product Literature References

Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells: H.M. De Busser, et al.; Int. J. Biochem. Cell Biol. 32, 1007 (2000), Abstract;

Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase: S.S. Szegedi, et al.; Nucl. Acids Res. 28, 3962 (2000), Abstract;

The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism: G. Schluckebier, et al.; J. Mol. Biol. 289, 277 (1999), Abstract;

Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI: J.M. Zingg, et al.; Biochem. J. 332, 223 (1998), Abstract;

Two intertwined methylation activities of the MmeI restriction- modification class-IIS system from Methylophilus methylotrophus: J. Tucholski, et al.; Gene 223, 293 (1998), Abstract;

Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI: G. Schluckebier, et al.; J. Mol. Biol. 265, 56 (1997), Abstract;

Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus- induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA: W.K. Long, et al.; J. Virol. 61, 221 (1987), Abstract;

Sinefungin, a potent inhibitor or S-adenosylmethionine: protein O- methyltransferase: R.T. Borchardt, et al.; BBRC 89, 919 (1979), Abstract;

A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation: R.L. Hamil & M.M. Hoehn (Tokyo); J. Antibiot. 26, 463 (1973), Abstract;