Replaces Prod. #: BML-GR318
Anthracycline anticancer antibiotic. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase I and II. Inhibits RNA and DNA synthesis. Induces DNA single strand breaks and apoptosis in tumor cells.
Product Details
| Alternative Name: | Daunomycin . HCl |
| |
| Formula: | C27H29NO10 . HCl |
| |
| MW: | 527.5 . 36.5 |
| |
| Source: | Isolated from Streptomyces spec. |
| |
| CAS: | 23541-50-6 |
| |
| MI: | 14: 2832 |
| |
| Purity: | ≥90% (Assay) |
| |
| Appearance: | Orange to red crystalline powder. |
| |
| Solubility: | Soluble in water or methanol. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res.
34, 152 (2015),
Application(s): Cell culture,
Abstract;
Full Text
Signaling pathways activated by daunorubicin:: G. Laurent & J. P. Jaffrezou; Blood
98, 913 (2001), Review,
Abstract;
Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells: J. Chen, et al.; Biochim. Biophys. Acta.
1488, 219 (2000),
Abstract;
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin: D.A. Gewirtz; Biochem. Pharmacol.
57, 727 (1999),
Abstract;
Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: influence of drug transport abnormalities: M.G. Come, et al.; Int. J. Cancer
81, 580 (1999),
Abstract;
Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia: X.F. Hu, et al.; Blood
93, 4086 (1999),
Abstract;
Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells: K.J. Turnbull, et al.; Leukemia
13, 1056 (1999),
Abstract;
Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis: A. Bettaieb, et al.; Mol. Pharmacol.
55, 118 (1999),
Abstract;
Implication of radical oxygen species in ceramide generation, c-Jun N- terminal kinase activation and apoptosis induced by daunorubicin: V. Mansat-de Mas, et al.; Mol. Pharmacol.
56, 867 (1999),
Abstract;
The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines: I. Plo, et al.; FEBS Lett
452, 150 (1999),
Abstract;
Characterization of covalent adriamycin-DNA adducts: S.M. Zeman, et al.; PNAS
95, 11561 (1998),
Abstract;
Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells: M.P. Boland, et al.; J. Biol. Chem.
272, 12952 (1997),
Abstract;
Full Text
Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin: D.J. Taatjes, et al.; J. Med. Chem.
39, 4135 (1996),
Abstract;
Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals: R. Bose, et al.; Cell
82, 405 (1995),
Abstract;
