Antibiotic. Inhibitor of protein kinase C (PKC). Breaks the bacterial membrane by incorporating into the phospholipid of the outer membrane and activating phospholipase.
Product Details
| Source: | Synthetic. |
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| CAS: | 1405-20-5 |
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| MI: | 14: 7573 |
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| RTECS: | TR1150000 |
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| Purity: | ≥80% (HPLC) (sum of polymyxins B1, B2, B3, B1-I) |
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| Purity Detail: | Mixture of Polymyxin B1, B2, B3 and B1-I. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Polymyxin B1
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Product Literature References
Immune activation of vaginal human Langerhans cells increases susceptibility to HIV-1 infection: N.H.V. Teijlingen, et al.; Sci. Rep.
13, 3283 (2023),
Abstract;
The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes: S.P. Hoekstra, et al.; Cell Stress Chaperones
24, 461 (2019),
Application(s): experimental treatement- human male blood,
Abstract;
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule: D. Ferrari, et al.; Br. J. Pharmacol.
150, 445 (2007),
Abstract;
Polymyxin antibiotics for gram-negative infections: T. M. Arnold, et al.; Am. J. Health Syst. Pharm.
64, 819 (2007), Review,
Abstract;
Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion: B. Valentinis, et al.; J. Biol. Chem.
280, 14264 (2005),
Abstract;
Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells: A. Ngezahayo & H.A. Kolb; Pfluegers Arch.
422, 413 (1993),
Abstract;
Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action: A. Guma, et al.; Biosci. Rep.
12, 413 (1992),
Abstract;
Volume-regulatory Cl- channel currents in cultured human epithelial cells: M. Kubo & Y. Okada; J. Physiol.
456, 351 (1992),
Abstract;
Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B & cardiotoxin. Differential inhibition of PKC, CaMKII & synaptosomal membrane Na,K-ATPase & Na+ pump & differentiation of HL60 cells.: R.L. Raynor, et al.; J. Biol. Chem.
266, 2753 (1991),
Abstract;
Full Text
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine: C. Schächtele, et al.; BBRC
151, 542 (1988),
Abstract;
