Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis.
Product Details
| MW: | 791.1 (Oligomycin A) |
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| Source: | Isolated from Streptomyces diastatochromogens. |
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| CAS: | 1404-19-9 |
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| MI: | 14: 6833 |
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| RTECS: | RK3325000 |
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| Purity: | ≥90% (HPLC, TLC) |
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| Purity Detail: | Mixture of oligomycin A (major component), B, and C. |
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| Appearance: | White to faint yellow powder. |
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| Solubility: | Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc.
3, 101119 (2022),
Abstract;
Full Text
Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER: D.M. Booth, et al.; Mol. Cell
81, 3866 (2021),
Abstract;
Full Text
Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics: A. Klusoczki, et al.; Sci. Rep.
9, 5823 (2019),
Abstract;
Full Text
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen: M. Deygas, et al.; Nat. Commun.
9, 4545 (2018),
Abstract;
Full Text
UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy: A.C. Bento, et al.; Sci. Rep.
8, 12415 (2018),
Abstract;
Full Text
Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury: R.L. Hill, et al.; Neurochem. Int.
111, 45 (2017),
Abstract;
The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions: S. Koob, et al.; Biochim. Biophys. Acta
1853, 1551 (2015),
Application(s): Cell Culture,
Abstract;
Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions: R. Dawaliby, et al.; Mol. Biol. Cell
21, 4173 (2010),
Abstract;
Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol.
109, 221 (2000),
Abstract;
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ.
7, 477 (2000),
Abstract;
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem.
273, 15628 (1998),
Abstract;
Full Text
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett.
339, 40 (1994),
Abstract;
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett.
315, 233 (1993),
Abstract;
Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther.
264, 515 (1993),
Abstract;
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta
1141, 231 (1993),
Abstract;
