Ionophore antibiotic. Inhibitor of the S. cerevisiae ABC transporter Pdr5p.Inhibitor of acyl-CoA-cholesterol acyltransferase and of phosphodiesterase. Potential anticancer compound.
Product Details
| Formula: | C33H57N3O9 |
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| MW: | 639.8 |
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| Source: | Isolated from Fusarium orthoceras var. enniatum. |
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| CAS: | 917-13-5 |
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| MI: | 14: 3585 |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in DMSO or other organic solvents; almost insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Beauvericin and enniatin B effects on a human lymphoblastoid Jurkat T-cell model: L. Manyes, et al.; Food Chem. Toxicol.
115, 127 (2018),
Abstract;
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res.
54, 87 (2015),
Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis,
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Toxic indole alkaloids avrainvillamide and stephacidin B produced by a biocide tolerant indoor mold Aspergillus westerdijkiae: R. Mikkola, et al.; Toxicon.
99, 58 (2015),
Application(s): Cell Culture ,
Abstract;
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells: R. Dornetshuber, et al.; Chem. Res. Toxicol.
20, 465 (2007),
Abstract;
Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae: K. Hiraga, et al.; Biochem. Biophys. Res. Commun.
328, 1119 (2005),
Abstract;
Interaction of cyclic peptides and depsipeptides with calmodulin: K.A. Mereish, et al.; Pept. Res.
3, 233 (1990),
Abstract;
"Sandwich" complexation in cyclopeptides and its implications in membrane processes: V.T. Ivanov; Ann. N. Y. Acad. Sci.
264, 221 (1975),
Abstract;
Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria: E. Gaumann, et al.; Experientia 3, 202 (1947),
