Inhibitor of the Raf/MEK-1/MAPK cascade (IC50= 539nM).
Product Details
| Formula: | C8H7BrN2O2 |
| |
| MW: | 243.1 |
| |
| Source: | Isolated from sponge Pseudaxynissa sp. |
| |
| CAS: | 96562-96-8 |
| |
| Purity: | ≥96% (HPLC) |
| |
| Identity: | Identity determined by 1H-NMR and ESI-MS. |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in DMSO or 100% ethanol. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
CD40L mediated alternative NFκB-signaling induces resistance to BCR-inhibitors in patients with mantle cell lymphoma: H. Rauert-Wunderlich, et al.; Cell Death Dis.
9, 86 (2018),
Abstract;
Full Text
Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin: F. Tutino, et al.; Tetrahedron 65, 2372 (2009),
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa: A. Aiello, et al.; Bioorg. Med. Chem.
14, 17 (2006),
Abstract;
Synthesis and target identification of hymenialdisine analogs: Y. Wan, et al.; Chem. Biol.
11, 247 (2004),
Abstract;
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem.
45, 529 (2002),
Abstract;
Anti-Cancer Metabolites from Marine Sponges: D. Tasdemir; Biodiversity: Biomolecular Aspects of Biodiversity and Innovative Utilization 187 (2002), (Book),
Abstract;
Total syntheses of hymenialdisine and debromohymenialdisine: Stereospecific construction of the 2-amino-4-oxo-2-imidazolin-5(Z)-disubstituted y ylidene ring system: H. Annoura & T. Tatsuoka; THL 36, 413 (1995),
Marine natural products: pyrrololactams from several sponges: F.J. Schmitz, et al.; J. Nat. Prod.
48, 47 (1985),
Abstract;
