A-type proanthocyanidin contained in several plant species such as Laurus nobilis L. , Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum, Lindera umbellata, Metaxya rostrata. Potent antioxidant, TEAC method (nM Trolox) = 0.95. Protective agent against oxidative stress and apoptosis in human platelets.
Inhibitory activity against cyclooxygenase-2 (COX-2) in vitro.
DPPH radical scavenging IC50 6.14µM
Lipid peroxidation inhibition 159.74
Nitric oxide inhibition 10.28
Antibacterial against B.subtilis (9mm, 20mg/ml)
Product Details
| Alternative Name: | Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin |
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| Formula: | C45H36O18 |
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| MW: | 864.7 |
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| Source: | Isolated from Laurus nobilis L. |
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| CAS: | 88082-60-4 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Brown solid. |
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| Solubility: | Soluble in 100% ethanol, methanol or in a mixture of DMSO and water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Ethanol reduces kainate-evoked glutamate secretion in rat hippocampal astrocytes: P. Santofimia-Castano, et al.; Brain Res.
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Abstract;
Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties : T.O. Idowu, et al.; Phytochemistry
71, 2092 (2010),
Abstract;
Effect of cinnamtannin B-1 on CCK-8-evoked responses in mouse pancreatic acinar cells: R. Rivera-Barreno, et al.; Clin. Exp. Pharmacol. Physiol.
37, 980 (2010),
Abstract;
Increased calcium influx in the presence of ethanol in mouse pancreatic acinar cells: A. Del Castillo-Vaquero, et al.; Int. J. Exp. Pathol.
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Abstract;
Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells: M. Fernandez-Sanchez, et al.; BMC Cell Biol.
10, 77 (2009),
Abstract;
Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion: S. Dall'Acqua, et al.; J. Med. Food
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Abstract;
Chemical and Pharmacological Investigations of Metaxya rostrata: J. Wirtbauer, et al.; Z. Naturforsch.
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Abstract;
Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor: J.J. López, et al.; Life Sciences
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Abstract;
Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem.
50, 3937 (2007),
Abstract;
Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis
12, 489 (2007),
Abstract;
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys.
457, 235 (2007),
Abstract;
Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem.
54, 1672 (2006),
Abstract;
Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia
59, 97 (2004),
Abstract;
Studies on the constituents of bark of Parameria laevigata Moldenke: K. Kamiya, et al.; Chem. Pharm. Bull.
49, 551 (2001),
Abstract;
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Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol.
51, 1075 (1999),
Abstract;
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod.
55, 1033 (1992),
Abstract;
Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice: N. Ezaki, et al.; Planta Med.
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Abstract;
