(S)-Enantiomer of the CDK inhibitor roscovitine (Prod. No. BML-CC205). Potent inhibitor of CDK1/cyclin B kinase (IC50=950nM).
Product Details
| Alternative Name: | 6-Benzylamino-2-(S)-[(1-Ethyl)-2-hydroxyethylamino]-9-isopropylpurine |
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| Formula: | C19H26N6O |
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| MW: | 354.5 |
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| CAS: | 186692-45-5 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation: V. Yarotskyy, et al.; J. Biol. Chem.
285, 43 (2010),
Abstract;
In vitro maturation and fertilization of porcine oocytes after a 48 h culture in roscovitine, an inhibitor of p34cdc2/cyclin B kinase: R. Romar & H. Funahashi; Anim. Reprod. Sci.
92, 321 (2006),
Abstract;
Maintenance of meiotic arrest in bovine oocytes using the S-enantiomer of roscovitine: effects on maturation, fertilization and subsequent embryo development in vitro: P. Coy, et al.; Reproduction
129, 19 (2005),
Abstract;
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res.
245, 8 (1998),
Abstract;
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem.
40, 408 (1997),
Abstract;
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine: W.F. De Azevedo, et al.; Eur. J. Biochem.
243, 518 (1997),
Abstract;
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