Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Details
| Formula: | C21H22O5 |
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| MW: | 354.4 |
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| Source: | Isolated from hops (Humulus lupulus). |
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| CAS: | 569-83-5, 6754-58-1 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Identity determined by NMR. |
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| Appearance: | Yellow to orange powder. |
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| Solubility: | Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes: S. Goenka & S.R. Simon; Biochem. Biophys. Rep.
26, 100955 (2021),
Abstract;
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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Prostate Cancer Cells after Treatment with Xanthohumol - A Natural Compound Present in Humulus lupulus L.: M. Klosek, et al.; Int. J. Mol. Sci.
17, e837 (2016),
Application(s): Cytotoxicity assay and detection of apoptotic cell death by flow cytometry,
Abstract;
Full Text
Endocrine Disrupting Compounds (EDCs): Disrupting Human Endocrine Physiology and the Intricate Reproductive Balance: S.A. Sidiropoulos; UTMJ
85, 76 (2008),
Abstract;
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis
12, 1953 (2007),
Abstract;
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry
65, 1317 (2004), (Review),
Abstract;
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther.
1, 959 (2002),
Abstract;
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica
30, 235 (2000),
Abstract;
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett.
149, 21 (2000),
Abstract;
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol.
37, 271 (1999),
Abstract;
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry
46, 683 (1997),
Abstract;
