Inhibitor of protein kinase C (PKC) (IC50=15µg/ml). Antiviral and antiretroviral activity. Potent inhibitor of dopamine-β-hydroxylase (IC50=3µg/ml).
Product Details
| Formula: | C30H16O9 |
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| MW: | 520.5 |
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| Source: | Isolated from Hypericum perforatum. |
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| CAS: | 55954-61-5 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | Black to black-red powder. |
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| Solubility: | Soluble in methanol, 100% ethanol, DMSO, acetone and other organic solvents. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antagonist effect of pseudohypericin at CRF1 receptors: U. Simmen, et al.; Eur. J. Pharmacol.
458, 251 (2003),
Abstract;
Phototoxic and apoptosis-inducing capacity of pseudohypericin: C.M. Schempp, et al.; Planta Med.
68, 171 (2002),
Abstract;
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids: A. Denke, et al.; Arzneimittelforschung
50, 415 (2000),
Abstract;
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC
165, 1207 (1989),
Abstract;
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin: G. Lavie, et al.; PNAS
86, 5963 (1989),
Abstract;
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS
85, 5230 (1988),
Abstract;
Zur Isolierung und Konstitution des Pseudohypericins : H. Brockmann, et al.; Tetrahedron Lett. 15, 1991 (1974),
