Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.
Product Details
| Formula: | C20H26O3 |
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| MW: | 314.2 |
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| Source: | Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans. |
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| CAS: | 6894-43-5 |
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| Purity: | ≥97% (UHPLC) |
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| Appearance: | White to yellow solid. |
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| Solubility: | Soluble in ethyl acetate, acetone or DMSO; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells: H.G. Kim, et al.; Toxicol. Appl. Pharmacol.
217, 332 (2006),
Abstract;
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol.
40, 1155 (2002),
Abstract;
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis
19, 1369 (1998),
Abstract;
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat: W.W. Huber, et al.; Mutat. Res.
376, 115 (1997),
Abstract;
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol: B. Schilter, et al.; Carcinogenesis
17, 2377 (1996),
Abstract;
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice: L.K. Lam, et al.; J. Med. Chem.
30, 1399 (1987),
Abstract;
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res.
42, 1193 (1982),
Abstract;
The chemistry of the coffee-bean: I. Concerning the unsaponifiable matter of the coffee-bean oil. Preparation and properties of kahweol: R.O. Bengis & R.J. Anderson; J. Biol. Chem.
97, 99 (1932),
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