Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).
Product Details
| Alternative Name: | Qinghaosu |
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| Formula: | C15H22O5 |
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| MW: | 282.4 |
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| Source: | Isolated from the traditional Chinese anti-malarial herb Artemisia annua L. |
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| CAS: | 63968-64-9 |
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| MI: | 14: 817 |
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| RTECS: | KD4170000 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO or acetone; almost insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem.
6, 509 (2006), Review,
Abstract;
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem.
10, 2197 (2003), Review,
Abstract;
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett.
552, 141 (2003),
Abstract;
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest.
83, 1647 (2003),
Abstract;
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci.
20, 199 (1999), Review,
Abstract;
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994),
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev.
7, 29 (1987),
Abstract;
Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science
228, 1049 (1985),
Abstract;
