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Deguelin

COX-2 inhibitor



ALX-350-118-M025	25 mg	Inquire for pricing

ALX-350-118-M005	5 mg	Inquire for pricing
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Replaces Prod. #: BML-EI329

Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Premalignant and malignant human brochial epithelial cells are highly sensitive to deguelin compared to normal cells. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.

Product Details

Alternative Name:	[-]-Deguelin

Formula:	C₂₃H₂₂O₆

MW:	394.4

CAS:	522-17-8

MI:	14: 2863

RTECS:	DX1500000

Purity:	≥95% (HPLC)

Appearance:	White to yellow powder.

Solubility:	Soluble in acetone, acetonitrile, DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.: N. Hail, et al.; Apoptosis 9, 437 (2004), Abstract;

Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata: C. Ito, et al.; Planta Med. 70, 8 (2004), Abstract;

Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells: H.Y. Lee, et al.; Clin. Cancer Res. 10, 1074 (2004), Abstract;

Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells: H.Y. Lee; Biochem. Pharmacol. 68, 1119 (2004), Abstract;

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells: K.H. Chun, et al.; J. Natl. Cancer Inst. 95, 291 (2003), Abstract; Full Text

Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest: G. Murillo, et al.; Eur. J. Cancer 38, 2446 (2002), Abstract;

Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid: G.O. Udeani, et al.; Cancer. Res. 57, 3424 (1997), Abstract;