Truncated analog of α-Gal-Cer. Selectively induces IL-4, as opposed to IFN-γ. Offers protection in mouse against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Also offers protection against diabetes in NOD mice and against collagen induced arthritis. Stimulation of NKT cells with α-Gal-Cer results in release of a mixture of Th1 and Th2 cytokines, stimulation with OCH results in release of primarily Th2 cytokine.
Product Details
| Alternative Name: | (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-2-tetracosanoyl-aminononan-3,4-diol |
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| Formula: | C39H78NO9 |
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| MW: | 704.1 |
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| Purity: | ≥95% (1H-NMR and TLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO, 100% ethanol (warm) or methanol (warm). |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Handling: | After reconstitution, aliquot into glass vials. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Innate Immunity Drives the Initiation of a Murine Model of Primary Biliary Cirrhosis: C. H. Chang, et al.; PLoS One
10, e0121320 (2015),
Application(s): Injection in mouse,
Abstract;
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Glycolipids for natural killer T cells: P.B. Savage, et al.; Chem. Soc. Rev.
351, 771 (2006),
Abstract;
Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH: R.M. Ndonye, et al.; J. Org. Chem.
70, 10260 (2005),
Abstract;
Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (alpha-d-galactosyl)-2- tetracosanoylamino-1,3,4-nonanetriol: K. Murata, et al.; J. Org. Chem.
70, 2398 (2005),
Abstract;
