Potent, water soluble competitive PARP inhibitor (IC50=0.20µM and 0.24µM for PARP-1 and PARP-2 respectively).
Product Details
| Alternative Name: | 2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one |
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| Formula: | C8H10N2OS |
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| MW: | 182.2 |
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| CAS: | 284028-90-6 |
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| Purity: | ≥98% (HPLC (UV)) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in DMSO, methanol or water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats: H. Nakajima, et al.; Pharmacol. Exp. Ther.
312, 472 (2005),
Abstract;
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