Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC50=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC50=5.0µM).
Product Details
| Formula: | C21H12N2O9S2Na4 |
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| MW: | 592.4 |
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| CAS: | 20324-87-2 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Brown solid. |
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| Solubility: | Soluble in water, 100% ethanol or DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Hygroscopic. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem.
279, 23892 (2004),
Abstract;
Full Text
A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem.
30, 443 (2002),
Abstract;
