Very potent and water soluble PARP-1 inhibitor (IC50=45nM, 100% inhibition at 200nM). Shows cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
Product Details
| Alternative Name: | 1-Piperazineacetamide,4-[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuron]-N-(2,3-dihydro-1H-isoindol-4-yl)-1-one . 2HCl . 2H2O |
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| Formula: | C24H27N9O6 . 2HCl . 2H2O |
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| MW: | 537.5 . 73.0 . 36.0 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors
9, 173 (2016),
Application(s): Potency of inhibitors,
Abstract;
Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell
32, 57 (2008),
Abstract;
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1): P.G. Jagtap, et al.; Bioorg. Med. Chem. Lett.
14, 81 (2004),
Abstract;
