Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer's patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. BML-GR319) resistance on breast cancer cells.
Product Details
| Formula: | C15H8N2O2 |
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| MW: | 248.2 |
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| Source: | Synthetic. |
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| CAS: | 13220-57-0 |
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| Purity: | ≥98% (1H-NMR, HPLC) |
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| Identity: | Determined by 1H-NMR, 13C-NMR, IR, MS and UV. |
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| Appearance: | Yellow needles. |
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| Solubility: | Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month. |
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| Handling: | Protect from light and moisture. |
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| Scientific Background: | Tryptanthrin occurs as a natural product in various plants: Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria, Calanthe discolor, Phaius mishmensis, Strobilanthes cusia. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells: K. Iwaki, et al.; J. Ethnopharmacol.
134, 450 (2011),
Abstract;
Modulatory effects and action mechanisms of tryptanthrin on murine myeloid leukemia cells: H.L. Chan, et al.; Cell Mol. Immunol.
6, 335 (2009),
Abstract;
Full Text
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC
358, 79 (2007),
Abstract;
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull.
26, 365 (2003),
Abstract;
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med.
68, 875 (2002),
Abstract;
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med.
67, 411 (2001),
Abstract;
H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000),
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol.
407, 197 (2000),
Abstract;
Tuberculosis: a search for novel therapy starting with natural products: L.A. Mitschler & W. Baker; Med. Res. Rev.
18, 363 (1998),
Abstract;
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