Replaces Prod. #: BML-EI124
Naturally occuring phenolic compound found in many fruits, vegetables and herbs, including coffee. Shows anti-tumor, antiviral, antioxidant and anti-inflammatory effects. Inhibitor of 5- and 12-lipoxygenase (LO) (5-LO, IC50=3.7µM).
Product Details
| Alternative Name: | 3-(3,4-Dihydroxyphenyl)-2-propenoic acid, 3,4-Dihydroxycinnamic acid |
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| Formula: | C9H8O4 |
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| MW: | 180.2 |
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| Source: | Synthetic. |
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| CAS: | 331-39-5 |
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| MI: | 14: 1635 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | Off-white to brown crystalline solid. |
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| Solubility: | Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS, pH 7.2. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 2 years when stored at +20°C. Organic stock solutions are stable for at least 6 months when stored at –20°C. Store aqueous solutions of the product on ice and use within 12 hours of preparation. |
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| Handling: | Protect from oxygen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Anti-HIV activities of natural antioxidant caffeic acid derivatives: toward an antiviral supplementation diet: F. Bailly & P. Cotelle; Curr. Med. Chem.
12, 1811 (2005),
Abstract;
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res.
38, 1241 (2004),
Abstract;
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism: T.W. Chung, et al.; FASEB J.
18, 1670 (2004),
Abstract;
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives: N. Kohyama, et al.; Biosci. Biotech. Biochem.
61, 347 (1997),
Abstract;
Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon: C.V. Rao, et al.; Cancer Res.
53, 4182 (1993),
Abstract;
Caffeic acid is a selective inhibitor for leukotriene biosynthesis: Y. Koshihara, et al.; Biochim. Biophys. Acta
792, 92 (1984),
Abstract;
General Literature References
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells: I. Shureiqi, et al.; Cancer Res.
60, 6846 (2000),
Abstract;
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells: I. Shureiqi, et al.; J. Natl. Cancer Inst.
92, 1136 (2000),
Abstract;
Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon: H.C. Chiang, et al.; J. Enzyme Inhib.
8, 61 (1994),
Abstract;
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