Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.
Product Details
| Formula: | C14H13BrN2O |
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| MW: | 305.2 |
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| CAS: | 65678-07-1 |
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| Purity: | ≥98% (HPLC (UV)) |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in acetonitrile (5mg/ml), DMSO (8mg/ml), dichloromethane (23mg/ml) or methanol (5mg/ml); insoluble in 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | In a dissolved form it should be stable for at least 1 month. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells: A. Camirand & M. Pollak; Br. J. Cancer
90, 1825 (2004),
Abstract;
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins: M. Parrizas, et al.; Endocrinology
138, 1427 (1997),
Abstract;
Full Text
The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor: M. Ohmichi, et al.; Biochemistry
32, 4650 (1993),
Abstract;
