Replaces Prod. #: BML-CN252
Potent inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). More potent than 7-nitroindazole.
Product Details
| Formula: | C7H4BrN3O2 |
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| MW: | 242.0 |
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| CAS: | 74209-34-0 |
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| Purity: | ≥98% |
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| Appearance: | Yellowish solid. |
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| Solubility: | Soluble in DMSO (50mg/ml), methanol or 100% ethanol; also soluble in water containing 10% DMSO or in a 50:50 mixture of water:DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat: M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry
30, 56 (2006),
Abstract;
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism: C.S. Raman, et al.; Biochemistry
40, 13448 (2001),
Abstract;
3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles: S.C. Gammie, et al.; Brain Res.
870, 80 (2000),
Abstract;
Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro: J. Wu, et al.; Neuroscience
78, 393 (1997),
Abstract;
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy: D.B. Vaupel, et al.; Eur. J. Pharmacol.
324, 11 (1997),
Abstract;
7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase: P.A. Bland-Ward & P.K. Moore; Life Sci.
57, PL131 (1995),
Abstract;
