Irreversible, cell permeable inhibitor of caspase-4. Inhibits also caspase-5.
Product Details
| Alternative Name: | Caspase-4 inhibitor (fluoromethylketone) |
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| Sequence: | Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone |
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| MW: | 652.0 |
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| Formulation: | Liquid. In DMSO. |
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| Purity: | ≥95% (HPLC) |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles: G. Camilli, et al.; Eur. J. Immunol.
48, 757 (2018),
Abstract;
Full Text
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome: J.M. Platnich, et al.; Cell Rep.
25, 1525 (2018),
Abstract;
Keratin 8/18 breakdown and reorganization during apoptosis: B. Schutte, et al.; Exp. Cell Res.
297, 11 (2004),
Abstract;
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem.
278, 23786 (2003),
Abstract;
Full Text
