Inhibits papain and trypsin and to a small extent plasmin. Antipain is more specific for papain and trypsin than is leupeptin (Prod. No. ALX-260-009). The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.
Product Details
| Alternative Name: | [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl |
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| Sequence: | [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal |
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| Formula: | C27H44N10O6 . 2HCl |
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| MW: | 604.7 . 72.9 |
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| Source: | Synthetic. |
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| CAS: | 37682-72-7 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Activity: | Inhibitory Activity ≥30 U/mg (Trypsin, L-BAPA) |
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| Solubility: | Soluble in water, methanol, 100 % ethanol or acetonitrile. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest.
125, 4612 (2015),
Application(s): Skeletal muscle cell culture,
Abstract;
Full Text
Structures and activities of protease inhibitors of microbial origin: H. Umezawa; Meth. Enzymol.
45, 678 (1976),
Abstract;
Antipain, a new protease inhibitor isolated from actinomycetes: H. Suda, et al.; J. Antibiot.
25, 263 (1972),
Abstract;
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