Fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes and for the proteasome.
Product Details
| Alternative Name: | Z-VKM-AMC, Z-Val-Lys-Met-AMC |
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| Sequence: | Z-Val-Lys-Met-AMC (AMC=7-Amino-4-methylcoumarin) |
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| Formula: | C34H45N5O7S |
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| MW: | 667.8 |
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| Purity: | ≥98% |
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| Appearance: | White powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells: R.C. Gardner, et al.; Biochem. J.
346, 447 (2000),
Abstract;
Full Text
Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue: S. Ishiura, et al.; Neurosci. Lett.
115, 329 (1990),
Abstract;
