Fluorogenic substrate for caspase-4.
Product Details
| Alternative Name: | Caspase-4 substrate (fluorogenic) |
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| Sequence: | Ac-Leu-Glu-Val-Asp-AMC (AMC=7-Amino-4-methylcoumarin) |
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| Formula: | C32H43N5O11 |
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| MW: | 673.7 |
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| Peptide Content: | 75-95% |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO. Dilute with distilled water or buffer, pH 7.5. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Keep cool and dry. |
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| Technical Info/Product Notes: | AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation: H. Ahn, et al.; Antioxidants
11, 1923 (2022),
Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem.
272, 17907 (1997),
Abstract;
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