Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.
Product Details
| Alternative Name: | Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone) |
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| Sequence: | Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone |
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| Formula: | C30H43FN4O11 |
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| MW: | 654.7 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store stock solutions in aliquots at -20°C. |
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| Handling: | Packaged under inert gas. |
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| Technical Info/Product Notes: | We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci.
79, 442 (2022),
Abstract;
Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL: I.K. Kim, et al.; BBRC
277, 311 (2000),
Abstract;
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis: A. Khwaja & L. Tatton; Blood
94, 291 (1999),
Abstract;
Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide: E.A. Sweeney, et al.; FEBS Lett.
425, 61 (1998),
Abstract;
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal: D.A. Martin, et al.; J. Biol. Chem.
273, 4345 (1998),
Abstract;
Full Text
Role of caspases in immunotoxin-induced apoptosis of cancer cells: A. Keppler-Hafkemeyer, et al.; Biochemistry
37, 16934 (1998),
Abstract;
