Reversible inhibitor of caspase-4. Also inhibits caspase-5.
Product Details
| Alternative Name: | Caspase-4 inhibitor (aldehyde) |
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| Sequence: | Ac-Leu-Glu-Val-Asp-CHO |
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| Formula: | C22H36N4O9 |
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| MW: | 500.6 |
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| Formulation: | Lyophilized. |
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| Peptide Content: | 70-90%. |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in distilled water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions should be divided into aliquots and stored at -20°C. |
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| Handling: | Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release: T.A.T. Tran, et al.; PLoS One
14, e0214999 (2019),
Abstract;
Full Text
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps: G. Sollberger, et al.; Sci. Immunol.
3, eaar6689 (2018),
Abstract;
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: R.V. Talanian, et al.; J. Biol. Chem.
272, 9677 (1997),
Abstract;
Full Text
