Replaces Prod. #: BML-P415
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Caspase-3 IC50: 1,1µM
Caspase-6 IC50: 4,1µM
Less effective on the inhibition of caspase-1- and 8-like activities.
Inhibits hypoxia-induced apoptosis in neuroblastoma cells.
Product Details
Alternative Name: | Caspase family inhibitor, Z-Asp-CH2-DCB, Z-L-Asp-a-[2,6-(dichlorobenzoyl)oxy]methane |
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Formula: | C20H17Cl2NO7 |
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MW: | 454.3 |
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CAS: | 153088-73-4 |
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Purity: | ≥98% (TLC) |
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Appearance: | White to off-white powder. |
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Solubility: | Soluble in methanol (50mg/ml) or DMSO. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Use/Stability: | Stock solutions should be divided into aliquots and stored at -20°C. |
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Handling: | Keep cool and dry. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation: T. Krakauer; Clin. Diagn. Lab. Immunol.
11, 621 (2004),
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Full Text
Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction: Y. Chandrashekhar, et al.; J. Am. Coll. Cardiol.
43, 295 (2004),
Abstract;
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension: L. Taraseviciene-Stewart; FASEB J.
15, 427 (2001),
Abstract;
Full Text
Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest: C. Gajate, et al.; Cancer Res.
60, 2651 (2000),
Abstract;
Full Text
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer
86, 208 (2000),
Abstract;
LPS-induced signals in activation of caspase-3-like protease, a key enzyme regulating apoptotic cell damage into a macrophage-like cell line, J774.1, in the presence of cycloheximide: H. Karahashi & F. Amano; J. Leukoc. Biol.
66, 689 (1999),
Abstract;
Full Text
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells: U.K. Messmer et al.; Kidney Int.
55, 2322 (1999),
Abstract;
Full Text
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria: R. Araya, et al.; FEBS Lett.
439, 168 (1998),
Abstract;
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells: T. Mashima, et al.; BBRC
209, 907 (1995),
Abstract;
P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta- converting enzyme: R.E. Dolle, et al.; J. Med. Chem.
37, 563 (1994),
Abstract;