Competitive inhibitor of human serum aminopeptidase A, pig kidney leucine aminopeptidase, leucine aminopeptidase, tyrosine aminopeptidase, but not of aminopeptidase B. Has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases.
Product Details
| Alternative Name: | [(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl |
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| Formula: | C21H38N4O8 . HCl |
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| MW: | 474.6 . 36.5 |
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| Source: | Synthetic. |
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| CAS: | 100938-10-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in acetic acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats: A.M. Gómez, et al.; J. Sci. Food Agric.
103, 1660 (2023),
Abstract;
NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake: E. Alari-Pahissa, et al.; PLoS Pathog.
17, e1009868 (2021),
Abstract;
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes: D.H. Rich, et al.; J. Med. Chem.
27, 417 (1984),
Abstract;
Structure and Chemical Synthesis of Amastatin: H. Tobe, et al.; Agric. Biol. Chem. 43, 591 (1979),
Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes: T. Aoyagi, et al.; J. Antibiot. (Tokyo)
31, 636 (1978),
Abstract;
