Product Details
| Alternative Name: | P2X purinoceptor 7, P2RX7 |
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| Host: | Rabbit |
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| Immunogen: | Vector containing the cDNA of mouse purinergic receptor P2X7. |
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| UniProt ID: | Q9Z1M0 |
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| Species reactivity: | Mouse
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| Applications: | Flow Cytometry, ICC, IP, FUNC
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| Recommended Dilutions/Conditions: | Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
Immunoprecipitation (1:100-1:400)
Functional Application (1:100-1:400)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Functional Application: Blocking. |
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| Positive Control: | HEK cells transfected with an expression plasmid for mouse purinergic receptor P2X7 can be used as positive control. |
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| Formulation: | Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Histone deacetylase 3 represses cholesterol efflux during CD4 + T-cell activation: D. Wilfahrt, et al.; Elife
10, e70978 (2021),
Abstract;
A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes: F. Scheuplein, et al.; J. Autoimmun.
34, 145 (2011),
Abstract;
Full Text
Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells: S. Hong, et al.; J. Immunol.
183, 578 (2009),
Abstract;
Full Text
NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells: F. Scheuplein, et al.; J. Immunol.
182, 2898 (2009),
Abstract;
Full Text
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site: S. Adriouch, et al.; FASEB J.
22, 861 (2008),
Abstract;
Full Text
Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization: S. Adriouch, et al.; Cell. Immunol.
236, 72 (2005),
Abstract;
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor: M. Seman, et al.; Immunity
19, 571 (2003),
Abstract;
General Literature References
The P2X7 receptor: a key player in IL-1 processing and release: D. Ferrari, et al.; J. Immunol.
176, 3877 (2006), (Review),
Abstract;
Molecular properties of ATP-gated P2X receptor ion channels: C. Vial, et al.; Trends Pharmacol. Sci.
25, 487 (2004), (Review),
Abstract;
Molecular structure of P2X receptors: T.M. Egan, et al.; Curr. Top. Med. Chem.
4, 821 (2004), (Review),
Abstract;
Molecular physiology of P2X receptors: R.A. North; Physiol. Rev.
82, 1013 (2002), (Review),
Abstract;
Full Text
