| ADI-VAM-SV016-D | 50 µg | 269.00 USD |  |
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| ADI-VAM-SV016-F | 200 µg | 541.00 USD | |
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| Alternative Name: | Exocyst complex component 4 |
| Clone: | 14G1 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant rat rSec8. |
| UniProt ID: | Q62824 |
| GenBank ID: | U32498 |
| Source: | Purified from ascites. |
| Species reactivity: | Human, Mouse, Rat Bovine, Chicken, Dog, Fish, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep |
| Applications: | ICC, IHC (PS), IP, WB |
| Recommended Dilutions/Conditions: | Immunoprecipitation (12.5µg/ml) Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~110kDa by Western blot. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal. |
| Regulatory Status: | RUO - Research Use Only |
Brain (rat), (tissue extract) |
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| Rat brain extract, WB | Print as PDF | ||||||
| ADI-LYT-RB100-F | 200 µg | 225.00 USD | |
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Goat anti-mouse IgG, polyclonal antibody (AP conjugate) |
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| ELISA, WB | Print as PDF | ||||||
| ADI-SAB-101-J | 1 ml | 175.00 USD | |
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