Product Details
Alternative Name: | Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, SAP90 |
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Clone: | 6G6-1C9 |
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Host: | Mouse |
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Isotype: | IgG2a |
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Immunogen: | Recombinant rat PSD-95. |
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UniProt ID: | Q62108 |
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Source: | Purified from ascites. |
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Species reactivity: | Mouse, Rat Bovine
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Applications: | ICC, WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (12.5µg/ml) Western Blot (1:250, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~100kDa by Western blot. |
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Purity Detail: | Protein G affinity purified. |
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Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Postsynaptic density protein 95 kDa (PSD-95), also known as Synapse associated protein 90 kDa (SAP90), is a brain specific protein that is highly similar to the Drosophila dlg tumor suppressor protein. PSD-95 is a member of membrane associated proteins that are localized beneath the postsynaptic membrane of synapses in the CNS. PSD-95 interacts with NMDA receptor and Shaker-type K+ channels and contributes to their clustering and localization at the synaptic spines in hippocampal neurons and the pinceau terminal of cerebellar basket cells, respectively. |
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Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of bovine brain tissue extract, probed with PSD-95 mAb (6G6-1C9).
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Product Literature References
Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology: M. Kaneda, et al.; Sci. Rep.
8, 727 (2018),
Abstract;
Full Text
Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons: T. Imamura, et al. ; Eur. J. Neurosci.
16, 1313 (2002),
Application(s): ICC using rat samples,
Abstract;
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