Product Details
Alternative Name: | HSP56, Heat shock protein 56, FK506 binding protein 1A |
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Clone: | KN382/EC1 |
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Host: | Mouse |
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Isotype: | IgG1 |
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Immunogen: | Partially purified 9S rabbit uterine progesterone receptor. |
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UniProt ID: | P27124 |
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GenBank ID: | M84474 |
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Source: | Purified from mouse ascites. |
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Species reactivity: | Human, Mouse Bovine, Guinea pig, Hamster, Mink, Monkey, Rabbit
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Applications: | IHC, IP, WB
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Recommended Dilutions/Conditions: | Immunoprecipitation (10µg/ml) Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~59kDa by Western blot. |
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Purity Detail: | Protein G affinity purified. |
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Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | FKBP59, also known as Hsp56/p59 is an immunophilin that is a component of Hsp70/Hsp90/steroid receptor complexes. Expression of FKBP59 is increased in response to heat shock and ischemic stress, and is thought to play a role in the folding and cytoplasmic/nuclear distribution of steroid receptors. |
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Technical Info/Product Notes: | Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000004478). |
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Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of FKBP59 mAb (KN382/EC1) (Prod. No. ADI-SRA-1400): Lane 1: MW marker, Lane 2: HeLa Cell Lysate(heat shocked), Lane 3: MDBK Celll Lysate (heat shocked), Lane 4: VERO Cell Lysate (heat shocked), Lane 5: RK-13 Cell Lysate (heat shocked).
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Product Literature References
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain: S. Tsutsumi, et al. ; Nat. Struct. Mol. Biol.
16, 1141 (2009),
Application(s): WB, IP using mouse cell lysates,
Abstract;
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex: R. Voellmy, et al. ; J. Biol. Chem.
276, 45791 (2001),
Application(s): WB using human samples,
Abstract;
Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506: H.S. Gordon, et al. ; J. Pharmacol. Exp. Ther.
289, 1202 (1999),
Application(s): Other using human samples,
Abstract;
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