Product Details
| Alternative Name: | PDIA3, ERp60, ERp61, GRP57, Grp58 |
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| Host: | Rabbit |
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| Immunogen: | Native rat liver ERp57. |
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| UniProt ID: | P11598 |
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| Gene/Protein Identifier: | NM_017319 (RefSeq) |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Human, Mouse, Rat
Bovine, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit
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| Applications: | IHC (PS), WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~57kDa by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | ERp57 (also known as Grp58), a member of the Thioredoxin superfamily, is an ER protein with disulfide isomerase activity. It has been shown to increase after oncogenic transformation and to be a component of the MHC Class I peptide-loading complex. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of ERp57 (Grp58): Lane 1: MW marker, Lane 2: CHO-K1 lysate, Lane 3: Human Liver Microsomes, Lane 4: Rat Liver Microsomes, Lane 5: Mouse Liver Microsomes.
Immunohistochemistry analysis of human colon tissue stained with ERp57, pAb at 10µg/ml.
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Product Literature References
Cnpy32xHA mice reveal neuronal expression of Cnpy3 in the brain: Md. M. Islam, et al.; J. Neurosci. Methods
383, 109730 (2023),
Abstract;
Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung: N. Chamberlain, et al.; Int. J. Mol. Sci.
23, 1078 (2022),
Abstract;
Comparative proteome analysis of monolayer and spheroid culture of canine osteosarcoma cells: C. Gebhard, et al.; J. Proteomics
177, 124 (2018),
Application(s):IHC,
Abstract;
HLA-G peptide preferences change in transformed cells: impact on the binding motif: A.A. Celik, et al.; Immunogenetics
70, 485 (2018),
Abstract;
Full Text
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration: V. Castillo, et al.; PLoS One
10, e0136620 (2015),
Application(s): Densitometry analysis Western blot,
Abstract;
Full Text
Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes: S. Badrinath, et al.; Haematologica
97, 98 (2012),
Abstract;
Full Text
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