Product Details
| Alternative Name: | Superoxide Dismutase (Cu-Zn), Superoxide dismutase 1, SOD1 |
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| Host: | Rabbit |
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| Immunogen: | Native rat Cu/Zn SOD. |
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| UniProt ID: | P07632 |
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| Gene/Protein Identifier: | NP_058746 (RefSeq) |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (0.5µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~23kDa (human) or ~19kDa (other species) by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD). |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis: rat brain tissue extract, probed with Cu/Zn SOD pAb.
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Product Literature References
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis: S. Bhaskaran, et al.; Redox Biol.
59, 102550 (2023),
Abstract;
Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord: B.G. Trist, et al.; Brain
145, 3108 (2022),
Abstract;
PPARγ as an indicator of vascular function in an experimental model of metabolic syndrome in rabbits: S. Guerra-Ojeda, et al.; Atherosclerosis
332, 16 (2021),
Abstract;
Nitric oxide and oxidative stress pathways do not contribute to sex differences in renal injury and function in Dahl SS/Jr rats: H.R. Turbeville, et al.; Physiol. Rep.
13, e14440 (2020),
Abstract;
Full Text
Chronic exercise impairs nitric oxide pathway in rabbit carotid and femoral arteries: P. Marchio, et al.; J. Physiol.
596, 4361 (2018),
Abstract;
Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats: T. Shibaguchi, et al.; Physiol. Rep.
4, e12885 (2016),
Application(s): SDS-PAGE and western blotting,
Abstract;
Full Text
Scheme of Ischaemia-triggered Agents during Brain Infarct Evolution in a Rat Model of Permanent Focal Ischaemia: P. Bonova, et al.; J. Mol. Neurosci.
57, 73 (2015),
Application(s): Western Blot,
Abstract;
S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2: E. Garcia, et al.; Free Radic. Res.
48, 159 (2014),
Application(s): Western Blot of stratial & nigral mouse tissue lysates,
Abstract;
A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice: D. Jaarsma, et al. ; Hum. Mol. Genet.
17, 2849 (2008),
Application(s): WB using mouse tissue,
Abstract;
Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis: H.D. Durham, et al. ; J. Biol. Chem.
276, 12791 (2001),
Application(s): WB using human samples,
Abstract;
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