| ADI-KAP-TK005-E | 100 µl | 381.00 USD |  |
||
| Do you need bulk/larger quantities? | |||||
| Alternative Name: | CD117 |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide for C-terminal of human c-Kit. |
| UniProt ID: | P10721 |
| Species reactivity: | Human |
| Applications: | IHC (PS), WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 1:200) Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A-affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | c-Kit, also known as CD117 and Stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit protooncogene. c-Kit regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis, and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. |
| Regulatory Status: | RUO - Research Use Only |
