Alternative Name: | Interleukin-1 receptor-associated kinase 4 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human IRAK-4. |
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UniProt ID: | Q9NWZ3 |
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Species reactivity: | Human
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Applications: | ICC, WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (10µg/ml)
Western Blot (1-4µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~50kDa by Western blot. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | -20°C |
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Scientific Background: | IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of IL-1 induced activation of the NF-κB pathway. IL-1 stimulates the association of IRAK with the heterodimer of IL-IRI and IL-IRAcP via the adapter protein MyD88. In addition to its role in IL-1 signaling, IRAK is a component of the signal transduction pathway through which TNF-R1 activates NF-κB dependent gene expression. |
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Regulatory Status: | RUO - Research Use Only |
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