| ADI-KAP-MA010-E | 100 µg | 372.00 USD |  |
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| Alternative Name: | MKK1, MAP kinase kinase 1 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human MEK1. The sequence is completely conserved in mouse, rat, hamster, rabbit and Xenopus. |
| UniProt ID: | Q02750 |
| GenBank ID: | L05624 |
| Source: | Purified from rabbit serum. |
| Species reactivity: | Human, Mouse, Rat Xenopus |
| Applications: | IF, IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1:50) Western Blot (1µg/ml, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~48kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. |
| Regulatory Status: | RUO - Research Use Only |
