| ADI-KAM-CC200-E | 100 µg | 353.00 USD |  |
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| Alternative Name: | CCND1 |
| Clone: | 5D4 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Immunogen: | Recombinant human cyclin D1. |
| UniProt ID: | P24385 |
| Species reactivity: | Human, Mouse |
| Applications: | Flow Cytometry, ICC, IHC (PS), IP, WB |
| Recommended Dilutions/Conditions: | Flow Cytometry (10µg/ml final concentration) Immunohistochemistry (10µg/ml, frozen/paraffin) Immunoprecipitation (1-10µg/200µg cell extract from 5x106 cells) Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~36kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Cyclins are a family of proteins which function as the regulatory subunits of cyclin/cyclin-dependent kinase (Cdk) holoenzymes, mediating entry into and progression through the cell cycle. Each cyclin is expressed in a temporal fashion during the cell cycle, partnering with a specific Cdk to activate its protein kinase activity. The most well defined mitotic cyclins are: cyclin D, which partners with cdks 4 and 6 during early G1 phase; cyclin E, which activates Cdk2 in the G1 to S phase transition; cyclin A, which utilizes Cdks 1 and 2 during progression through S phase and into G2; and cyclin B, which activates Cdk1 in M-phase promotion. |
| Regulatory Status: | RUO - Research Use Only |
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