| ADI-CSA-815-D | 50 µg | 269.00 USD |  |
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| ADI-CSA-815-F | 200 µg | 528.00 USD | |
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| Alternative Name: | Tumor necrosis factor receptor 1, TNF-R1 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to a portion of mouse TNF-R1. The sequence is completely conserved in rat and human. |
| UniProt ID: | P25118 |
| GenBank ID: | X59238 |
| Source: | Purified from rabbit serum. |
| Species reactivity: | Human, Mouse, Rat Bovine, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus, Yeast |
| Applications: | IHC (PS), IP, WB |
| Recommended Dilutions/Conditions: | Immunoprecipitation (12.5µg/ml) Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of 55kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis. |
| Regulatory Status: | RUO - Research Use Only |
HeLa (heat shocked) , (cell lysate) |
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| Human, WB | Print as PDF | ||||||
| ADI-LYC-HL101-F | 200 µg | 141.00 USD | |
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Jurkat, (cell lysate) |
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| Human, WB | Print as PDF | ||||||
| ADI-LYC-JK100-F | 200 µg | 143.00 USD | |
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