Product Details
| Alternative Name: | Interleukin-1 receptor-associated kinase 1 |
| |
| Host: | Rabbit |
| |
| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human IRAK-1. |
| |
| UniProt ID: | P51617 |
| |
| Species reactivity: | Human, Mouse, Rat
|
| |
| Applications: | ICC, IP, WB
|
| |
| Purity Detail: | DEAE purified. |
| |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Scientific Background: | IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of IL-1 induced activation of the NF-κB pathway. IL-1 stimulates the association of IRAK with the heterodimer of IL-IRI and IL-IRAcP via the adapter protein MyD88. In addition to its role in IL-1 signaling, IRAK is a component of the signal transduction pathway through which TNF-R1 activates NF-κB dependent gene expression. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Immunocytochemistry analysis of IRAK in HeLa cells with IRAK antibody at 10µg/ml.
Western blot analysis of IRAK in THP-1 (THP) and HeLa (HL) whole cell lysates with IRAK antibody at 1:2000 dilution.
Please mouse over
Product Literature References
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways: H.F. Huang, et al.; World J. Gastroenterol.
21, 2937 (2015),
Application(s): Western Blotting,
Abstract;
Full Text
