Product Details
| Alternative Name: | TACE, A disintegrin and metalloproteinase 17 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human ADAM17. |
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| UniProt ID: | P78536 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | ICC, WB
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| Recommended Dilutions/Conditions: | Western Blot (1:500-1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects bands of ~80 to ~130kDa (may represent mature protein, precursor, and glycosylated TACE) by Western blot. |
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| Purity Detail: | Peptide affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of TACE in HeLa and Jurkat whole cell lysate in the absence or presence of blocking peptide with TACE antibody at 1:500 dilution.
Immunocytochemistry analysis of TACE in HeLa cells with TACE antibody at 10µg/ml.
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Product Literature References
GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin: S.O. Mattila, et al.; FASEB J.
35, e21654 (2021),
Abstract;
Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease: B. Ray, et al.; Transl. Psychiatry
10, 81 (2020),
Abstract;
Full Text
High Glucose Upregulates ADAM17 through HIF-1α in Mesangial Cells: R. Li, et al.; J. Biol. Chem.
290, 21603 (2015),
Application(s): Immunofluorescence,
Abstract;
Full Text
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