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SCREEN-WELL® Toxicity Libraries

SCREEN-WELL® libraries from Enzo Life Sciences for nephrotoxicity, cardiotoxicity, hepatotoxicity, and hematopoietic toxicity contain compounds with defined and diverse organ-associated toxicity profiles. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500μl per well. The libraries are useful for predictive toxicology screening, including high-content protocols using cell based assays for early safety assessment.

  • Hundreds of compounds of defined and diverse toxicity
  • Nontoxic controls also included
  • Dissolved in DMSO and supplied in 96 well plates

Predictive Toxicology Using Cell Systems
Comparison of lead compound results with those from compounds of known toxicity allows early elimination of toxic candidates.

 

Major toxicity categories covered include:

Cardiotoxicity Library

Ion channel blockage
Cardiomyocyte apoptosis
Mitochondrial toxicity
Thrombosis
Arrythmia
Hypotension/hypertension
Fibrosis & carditis
Non-cardiotoxic controls

Hepatotoxicity Library

Steatosis Compounds
Cholestatic effects
Mitochondrial toxicity
Cytochrome P450 Inactivation
Toxic metabolites
Mallory body formation
Elevation of liver enzymes
Non-hepatotoxic controls

Hematopoietic Toxicity Library

Myelosuppression
Leukopenia
Neutropenia
Anemia
Thrombocytopenia
Hematopoietically nontoxic controls

Myotoxicity Library

Rhabdomyolysis
Cardiomyopathy
Inflammatory myopathy
Metabolic abnormality
Mitrochondrial myopathy
Reversible myopathy
Skeletal myopathy
Vacuolar myopathy

Nephrotoxicity Library

Analgesic nephropathy
Interstitial nephritis
Glomerularopathy
Proximal and distal tubulopathy
Diabetes insipidus
Acute renal failure
Chronic kidney disease
Non-nephrotoxic controls

SCREEN-WELL® Myotoxicity library 

Essential standards for predictive toxicology screening
HTS | Print as PDF
 
ENZ-LIB101-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

SCREEN-WELL® Nephrotoxicity library 

Essential standards for predictive toxicology screening
HTS | Print as PDF
 
ENZ-LIB100-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

SCREEN-WELL® Cardiotoxicity library 

Essential standards for predictive toxicology screening
HTS | Print as PDF
 
BML-2850-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2850-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

SCREEN-WELL® Hepatotoxicity library 

Essential standards for predictive toxicology screening
HTS | Print as PDF
 
BML-2851-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2851-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

SCREEN-WELL® Hematopoietic Toxicity library 

Essential standards for predictive toxicology screening
HTS | Print as PDF
 
BML-2852-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2852-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

SCREEN-WELL® Epigenetics library 

HTS | Print as PDF
 
BML-2836-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2836-0100 1 Library 100 µl/well Inquire for pricing
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SCREEN-WELL® Autophagy library 

Structurally and mechanistically different compounds for studying the roles of pro- and anti-autophagic molecules in cells and in vitro applications.
HTS | Print as PDF
 
BML-2837-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2837-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

SCREEN-WELL® Wnt Pathway library 

Compounds are highly relevant; many are unique
HTS | Print as PDF
 
BML-2838-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2838-0100 1 Library 100 µl/well Inquire for pricing
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SCREEN-WELL® Compound Libraries

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