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FLUOR DE LYS® HDAC & Sirtuin Assays

Convenient Screening Formats from the Pioneer in Non-Radioactive Assays

For over a decade, the FLUOR DE LYS® deacetylase assay platform has revolutionized assay of HDAC & Sirtuin enzyme activity, freeing researchers from cumbersome protocols required with radiolabeled or other modified histone-based methods. Our high-quality assays utilize patented substrate/developer chemistry in combination with high-activity, high-purity enzymes, to deliver more high-quality hits. Broad-class HDAC/Sirtuin screening assays are available in chemiluminescent, fluorescent, and colorimetric formats.

Flexible HDAC & Sirtuin Assays

  • Non-radioactive, homogeneous, HTS compatible formats
  • Green & chemiluminescent assays available to minimize interference
  • Assay all HDAC classes from multiple sources
  • High-activity, in-house manufactured control enzymes
  • Widely cited in peer- reviewed literature
 

FLUOR DE LYS substrates form the core of the Fluor de Lys Substrate/Developer system for measuring HDAC activity.

Featured FLUOR DE LYS References

  • Yuan J, Luo K, Liu T, Lou Z. Regulation of SIRT1 activity by genotoxic stress. Genes Dev. 2012 Apr 15;26 (8):791-6.
  • Zhang S, Cai G, Fu B, Feng Z, Ding R, Bai X, Liu W, Zhuo L, Sun L, Liu F, Chen X. SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence. Mech Ageing Dev. 2012 Jun;133 (6):387-400.
  • Wang Z, Li W, Meng X, Jia B. Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):227-32.
  • Vaidya AS, Karumudi B, Mendonca E, Madriaga A, Abdelkarim H, van Breemen RB, Petukhov PA. Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2. Bioorg Med Chem Lett. 2012 Jun 18. [Epub ahead of print]
 

Featured FLUOR DE LYS Assays

CHEMILUM DE LYS® HDAC/SIRT Chemiluminescent drug discovery kit 

All the Benefits of Chemiluminescent Detection Without Any of the Side Effects
Chemiluminescence, HTS, Activity assay | Print as PDF
 
BML-AK532-0001 96 wells 600.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® SIRT5 fluorometric drug discovery assay kit 

A Sensitive Fluorometric Assay for Screening SIRT5 Inhibitors
Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK513-0001 100 tests 618.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® Green SIRT5 fluorometric drug discovery assay kit 

A Sensitive Fluorometric Assay for Screening SIRT5 Inhibitors
Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK514-0001 100 tests 600.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® HDAC fluorometric activity assay kit 

First-to-market by the leader in Epigenetics research tools
Fluorescent detection, HTS, Activity assay | Print as PDF
 
BML-AK500-0001 96 wells 492.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS®-Green HDAC fluorometric activity assay kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK530-0001 96 wells 404.00 USD
Do you need bulk/larger quantities?
 

COLOR DE LYS® HDAC colorimetric activity assay kit 

Simplify HDAC activity analysis with the fastest colorimetric assay on the market
Colorimetric detection, HTS, Activity assay | Print as PDF
 
BML-AK501-0001 96 wells 404.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® HDAC fluorometric cellular activity assay kit 

Monitor HDAC activity in cell culture using cell-permeable FLUOR DE LYS® substrate
Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK503-0001 96 wells 445.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® HDAC1 fluorometric drug discovery assay kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK511-0001 96 wells 656.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® HDAC3/NCOR1 fluorometric drug discovery kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK531-0001 96 wells 656.00 USD
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FLUOR DE LYS® HDAC6 fluorometric drug discovery kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK516-0001 96 wells 656.00 USD
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FLUOR DE LYS® HDAC8 fluorometric drug discovery kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK518-0001 96 wells 656.00 USD
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FLUOR DE LYS® SIRT1 fluorometric drug discovery assay kit 

First-to-market by the leader in Epigenetics research tools
Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK555-0001 96 wells 656.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS® SIRT2 fluorometric drug discovery assay kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK556-0001 96 wells 656.00 USD
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FLUOR DE LYS® SIRT3 fluorometric drug discovery assay kit 

Fluorescent detection, HTS, Activity assay, Cell-based assays | Print as PDF
 
BML-AK557-0001 96 wells 643.00 USD
Do you need bulk/larger quantities?
 

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